It’s about a hundred times more expensive, but it may be the better choice anyway. In phase III studies for the treatment of gram-positive hospital-acquired (nosocomial) pneumonia, Linezolid (Zyvox canadian, Pharmacia & Upjohn) was superior to vancomycin (Vancocin® HCl, Eli Lilly), report researchers from Methodist University Hospital. Their findings were presented at an American Thoracic Society meeting in Seattle in May 2003.
Linezolid was particularly efficacious in treating methicillin-resistant Staphylococcus aureus (MRSA) pneumonia, and patients receiving linezolid were twice as likely to survive as patients who received vancomycin. The researchers explained that vancomycin is associated with renal toxicity, and patients at risk for renal problems might therefore be receiving underdoses. Linezolid is not associated with renal toxicity, and it seems to offer greater lung penetration.
Linezolid generic, which was approved in 2000, is the first FDA-approved oxazolidinone, a new class of antibiotics.