High blood glucose levels and intra-cranial hemorrhage are independent predictors of sudden worsening in patients with acute ischemic stroke who are receiving thrombolytic therapy, say researchers from University Hospitals of Cleveland and Case Western Reserve University.

In their study of 201 patients who received the therapy, 13% of the patients worsened, 39% improved, and the rest remained unchanged 24 hours after treatment was begun. The in-hospital mortality rate was 16%. No patients whose Stroke Scale score decreased died, compared with 73% of those whose scores increased.
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Patients who deteriorated were more likely to have hyperglycemia (above 150 mg/dl), even in the presence of recanalization. The findings support earlier research that hyperglycemia worsens the outcome for stroke patients.

A new class of drugs called incretin mimetics is offering hope to patients with type-2 (non-insulin-dependent) diabetes who have not been able to control their blood glucose levels after taking common oral regimens. Patients in phase III trials who received the investigational drug exenatide (synthetic extendin-4, Amylin/Eli Lilly) had lower blood glucose levels as well as improvements in markers of beta-cell function—and they lost weight to boot.

Researchers presented their findings from three studies at the 64th Annual Scientific Sessions of the American Diabetes Association.

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High blood glucose levels and intra-cranial hemorrhage are independent predictors of sudden worsening in patients with acute ischemic stroke who are receiving thrombolytic therapy, say researchers from University Hospitals of Cleveland and Case Western Reserve University.

In their study of 201 patients who received the therapy, 13% of the patients worsened, 39% improved, and the rest remained unchanged 24 hours after treatment was begun. The in-hospital mortality rate was 16%. No patients whose Stroke Scale score decreased died, compared with 73% of those whose scores increased.
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Patients who deteriorated were more likely to have hyperglycemia (above 150 mg/dl), even in the presence of recanalization. The findings support earlier research that hyperglycemia worsens the outcome for stroke patients.