Tadalafil (Cialis): Help for Erectile Dysfunction Caused by Spinal Cord Injury

CialisIn an international study, tadalafil (Cialis drug, Eli Lilly) improved erectile function in men with spinal cord injury.
After a four-week run-in period, 186 men (mean, 38 years of age) were randomly assigned to receive ondemand tadalafil or placebo for 12 weeks. The tadalafil dose was maintained at 10 mg/day or was titrated to 20 mg/day.

Most of the patients had had erectile dysfunction (ED) for at least one year; 69% had moderate-to-severe ED. The majority of men (78%) had a neurological injury at or above the T11 level. Yet despite serious baseline conditions, all primary efficacy variables improved significantly with tadalafil treatment improved ED from moderate at baseline to mild.

After 12 weeks, 54% of the patients had a normal domain score on the Interi national Index of Erectile Function; in fact, 40% of patients with severe ED at baseline achieved normal scores. The percentage of patients experiencing successful intercourse increased nearly fivefold, with 84% reporting improved erections.

The researchers believe that this was the first randomized, double-blind, placebo-controlled study of the efficacy and safety of generic tadalafil in such patients.

(Source: Arch Neurol 2007;64:1584-1592.)