For fast migraine relief without gastrointestinal symptoms, rofecoxib (Vioxx®, Merck), a long-acting selective cyclo-oxygenase-2 inhibitor, might be an answer. Researchers who conducted a parallel-group, multicenter study found the drug to be effective in just 30 minutes.
The researchers compared two doses of rofecoxib (25 and 50 mg) with placebo in 538 patients. Both doses were statistically superior to placebo in the acute treatment of a migraine attack as well as in relieving pain, photophobia, phono-phobia, nausea, and functional disability and in reducing the use of rescue medications. canadian discount pharmacy
The drug was well tolerated, and most clinical adverse events were mild to moderate in both treatment groups.