IV Ibuprofen (Caldolor) For Pain and Fever

IbuprofenAn intravenous (IV) formulation of ibuprofen (Caldolor), designed primarily for use in hospitals, is now available. Caldolor drug is the first injectable product available in the U.S. for the treatment of pain and fever.

The introduction of IV ibuprofen drug should help achieve improved pain control with less need for opioid analgesics and fewer opioid-related side effects. Until now, the only injectable drugs available to relieve pain were opioids, which can cause sedation, nausea, vomiting, cognitive impairment, and respiratory depression.

IV ibuprofen is indicated for alleviating mild-to-moderate pain, as an adjunct to opioid analgesics for alleviating moderate-to-severe pain, and for reducing fever in adults. It is contraindicated during the perioperative period for patients undergoing coronary artery bypass graft (CABG) surgery, and it should be used with caution in patients with a history of ulcer disease, gastrointestinal bleeding, fluid retention, renal impairment, heart failure, or liver impairment. Caution is also recommended for the elderly and for patients taking diuretics or angiotensin-converting enzyme (ACE) inhibitors.

Blood pressure should be monitored during IV ibuprofen treatment.

Approved in June 2009, the product is available in 400-mg and 800-mg vials.

Source: Cumberland, September 9, 2009