Diabetes Drugs and Fractures: Alert for Pioglitazone (Actos)

Diabetes Drugs

Health care professionals have been notified about recent safety data concerning products containing the anti-diabetes drug pioglitazone (Actos canadian, Takeda/Eli Lilly). Women with diabetes mellitus who were taking pioglitazone were reported to have experienced more fractures than those taking a comparator drug.

Most fractures observed were in the distal upper limb (forearm, hand, and wrist) or distal lower limb (foot, ankle, fibula, and tibia). The women were treated with drug pioglitazone for up to 3.5 years.

The Drug News column in the March issue of P&T also mentioned an increased risk of fractures in association with medication rosiglitazone (Generic Avandia, Avandamet, GlaxoSmithKline).