Ceftriaxone (Rocephin)

RocephinImportant revisions have been made to the Contraindications, Warnings, and Dosage and Administration sections of the full prescribing information for ceftriaxone (Rocephin, Roche).

This new information addresses the interaction of ceftriaxone with calcium-containing products based on reports of fatal cases in neonates. Although no cases of ceftriaxone-calcium precipitates in patients other than neonates have been reported, the potential for this interaction exists in patients of any age.

Generally, fatalities have been associated with simultaneous administration of ceftriaxone and calcium-containing products; however, administration of the two products at different times and via different infusion lines has also been fatal. Therefore, ceftriaxone should not be mixed with calcium-containing products or administered in the same or different infusion lines or sites in any patient within 48 hours of each other.

The information in the August 2007 ceftriaxone label clarifies the labeling revision in May 2007 that first included information on this interaction.

(Source: FDA, September 2007.)