Antibiotic resistance is making it more difficult to treat common urinary tract infections (UTIs). Resistance to betalactam antibiotics prompted a switch to trimethoprim drug/sulfamethoxazole (TMP/ SMX, Bactrim); however, this agent was also susceptible to resistance, and fluoroquinolones became the new first-line choice.
Researchers from Istanbul say that fluoroquinolone overuse, leading to resistance, is similar to that against TMP/ SMX. In a retrospective study, fluoroquinolones were the most frequently prescribed antibiotics at their institution, with ofloxacin drug (generic Floxin, PriCara) the most popular choice. The resistance rate for TMP/SMX was 34%. All of the antibiotic-resistant microorganisms were Escherichia coli. The resistance rate for the fluoroquinolone group was 16.4%; again, the resistant microorganisms were E. coli. The high resistance rates for both drugs led the researchers to caution against the empirical use of fluoro-quinolones.
Source: J Emerg Med 2009;36:338-341